Manchester City will welcome Liverpool in what promises to be the highlight of the FA Cup quarterfinals following the draw on Monday.
Struggling in Sky Bet League One, Port Vale will be making the trip to Chelsea for the quarterfinals.
Following their surprising victory over Sunderland on Sunday, Vale—currently sitting eight points from safety at the bottom of their league—are the lowest-ranked team still in the competition, making it to the quarterfinals for the first time since 1954.
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Chelsea had to rally from behind twice to secure a 4-2 extra-time win against 10-man Wrexham in a thrilling match at Stok Cae Ras.
Premier League leaders Arsenal, who triumphed over Mansfield on Saturday, will visit Championship side Southampton, who edged out Fulham 1-0 thanks to an injury-time penalty from Ross Stewart.
West Ham United, fresh from their victory over Brentford on Monday night, will play host to Leeds, who convincingly defeated Norwich 3-0.
The quarterfinal matches are scheduled to take place during the weekend of April 4.