This Friday night, Manchester United will host Newcastle United at Old Trafford, aiming to secure a favorable result in the Premier League. After a disappointing 2-1 defeat to Aston Villa in their last match, the Red Devils are determined to bounce back with a win against the Magpies.
Manager Ruben Amorim is expected to deploy a 3-4-2-1 formation and may make some adjustments to his starting lineup. With both Kobbie Mainoo and Bruno Fernandes unlikely to return in time for the match, Lisandro Martinez and Casemiro are set to start in the lineup.
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Predicted 3-4-2-1 Lineup for Manchester United Against Newcastle United
Defense
In goal, Senne Lammens will look to recover from conceding two goals in his last match. The defensive trio is likely to consist of Luke Shaw, Ayden Heaven, and Leny Yoro, who will aim to maintain a solid defensive structure.
Tyrell Malacia is expected to be available on the bench for defensive cover, while Harry Maguire will miss out due to injury.
BIRMINGHAM, ENGLAND – DECEMBER 21: Lamare Bogarde of Aston Villa is pressured by Matheus Cunha of Manchester United during their Premier League encounter at Villa Park on December 21, 2025. (Photo by Clive Mason/Getty Images)
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Midfield
Lisandro Martinez and Casemiro will serve as the midfield anchors for the Red Devils, focusing on gaining control in the center of the pitch.
On the left, Patrick Dorgu will look to impress, while Diogo Dalot will attempt to showcase his skills on the right wing, both players given the freedom to join attacking plays when possible.
Matheus Nunes and Mason Mount are expected to take on the roles of attacking midfielders, tasked with creating opportunities for Manchester United in the final third.
Attack
Up front, Benjamin Sesko will spearhead the attack, eager to find the back of the net against Newcastle.
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Joshua Zirkzee will likely start on the bench but may be introduced in the second half to make a crucial impact if Manchester United is in need of a goal.
Unfortunately, Bryan Mbeumo will be unavailable for this match due to injury.