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Leicester must secure a victory against sixth-placed Hull (kick-off at 19:45 BST) to keep their hopes of avoiding relegation to League One alive.
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Coventry faces Portsmouth at the CBS Arena, where a win would clinch the Championship title for them.
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If Millwall can manage a win or draw against Stoke, they will reclaim second place in automatic promotion. However, Southampton could surpass them by winning against Bristol City, assuming Millwall does not emerge victorious.
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A mistake by Hull at the King Power Stadium would allow Wrexham to climb back into the top six with a win over Oxford.
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The U’s are in urgent need of a win to narrow the gap with Blackburn to two points.
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Derby heads to Norwich aiming to maintain their play-off aspirations, while depending on other teams higher up the table to falter.
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Unless they face a points deduction, West Brom can ensure their safety with a win against Watford, with QPR hosting Swansea in another match of the evening.
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